An On-chip Whole Blood/plasma Sepa- Rator with Colloidal Silica Bead-packed Microchannel on Coc Polymer

A disposable on-chip whole blood/plasma separator, which is able to separate plasma from whole blood by capillary movement through a bead-packed microchannel, has been designed, fabricated and characterized in this work. Various sized silica beads were packed inside a microchannel using a slurry-bump pattern that prevented the beads from passing through the microchannel. The bead-packed microchannel impedes the movement of red blood cells (RBCs), resulting in plasma separation from whole blood. The developed separator provides a new approach to on-chip separation of plasma/serum for point-of-care testing (POCT).